Vascular Biology and Metabolism (VAM)

Overview

The Vascular Biology and Metabolism (VAM) area was created to enable a comprehensive, cooperative and multidisciplinary approach to research, development and transference of solutions for a group of diseases that are the leading cause of morbidity and mortality in the world: cardio- and neurovascular diseases, diabetes-metabolic syndrome and kidney failure.

This area also includes a group focused on Ophtalmology research and the Medical Molecular Imaging multidisciplinary group.

Publications

230

total

1,274.219

impact factor

5.542

average impact factor

Director: Anna Meseguer Navarro

team

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We focused our interests on inherited rare tubulopathies, tubular regeneration and cancer, fibrosis and FSGS. We consolidated the tubular injury/regeneration line in the pig model through a new MINECO project and the study of KIM-1/TIM-1/HAVCR1 role in ccRCC through the AACR (kure-it) project. pSTAT3 S727 was validated as a prognostic biomarker of overall survival in a second cohort of ccRCC patients and discovered that CK2-beta levels refine pSTAT3 S727 performance. We became Spain coordinators and co-chair of the ERKNet (European Rare Kidney Diseases Network) and strengthened research projects in Dent and FHHN rare diseases, in collaboration with Patients Associations (PA). International and national consortia have been created for Dent disease with Asdent PA support. We incorporated two Ph.D. students form Canada and Mexico and obtained a post-doctoral fellowship through a Marie-Curie action, as well as, a Ph.D. student from the PhD4MD program in collaboration with Dr. Vivek Malhotra at CRG.

16

total

43^.790

impact factor

2^.730

average impact factor

SELECTED ARTICLES

Vilardell J, Alcaraz E, Sarró E, Trilla E, Cuadros T, de Torres I, Plana M,, Ramón Y Cajal S, Pinna LA, Ruzzene M, Morote J, Meseguer A*, Itarte E*. *Senior co-authorship. Under-expression of CK2? subunit in ccRCC represents a complementary biomarker of p-STAT3 Ser727 that correlates with patient survival. 2017 Dec 19;9(5):5736-5751. doi: 10.18632/oncotarget.23422. IF: 5.168

De Quixano BB, Villena JA, Aranda M, Brils G, Cuevas A, Hespel T, Lekuona H, Súarez C, Tornavaca O, Meseguer A. Kidney Androgen-Regulated Protein (KAP) Transgenic Mice Are Protected Against High-Fat Diet Induced Metabolic Syndrome. Sci Rep. 2017 Nov 23;7(1):16102. doi: 10.1038/s41598-017-16487-y IF: 4.259

Jacobs-Cachá C, Torres IB, Lopez-Hellín J, Cantarell C, Azancot MA, Roman A, Moreso F, Serón D, Meseguer A*, Sarró E*.*Senior co-authorship. Fascin-1 is released from Proximal Tubular Cells in response to Calcineurin Inhibitors (CNIs) and correlates with isometric vacuolization in kidney transplanted patients. Am J Transl Res. 2017 Sep 15;9(9):4173-4183. PMID: 28979691 IF: 3.061

García Castaño A, Pérez de Nanclares G, Madariaga L, Aguirre M, Madrid Á, Chocrón S, Nadal I, Navarro M, Lucas E, Fijo J, Espino M, Espitaletta Z, García Nieto V, Barajas de Frutos D, Loza R, Pintos G, Castaño L; RenalTube Group, Ariceta G. Poor phenotype-genotype association in a large series of patients with Type III Bartter síndrome PLoS One. 2017 Mar 13;12(3):e0173581. doi: 10.1371/journal.pone.0173581. eCollection 2017 IF: 3.54

Segarra A, Romero K, Agraz I, Ramos N, Madrid A, Carnicer C, Jatem E, Vilalta R, Lara LE, Ostos E, Valtierra N, Jaramillo J, Arredondo KV, Ariceta G, Martinez C. Mesangial C4d Deposits in Early IgA Nephropathy. Clin J Am Soc Nephrol. 2018 Feb 7;13(2):258-264 doi: 10.2215/CJN.02530317 IF: 5.8

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Vascular Biology and Metabolism (VAM)

Overview

Publications

Director: Anna Meseguer Navarro

Research Areas