Digestive and Liver Diseases

Overview

The Digestive & Liver Diseases research area is composed by four groups, whose main goal is the study of the Digestive System diseases. In the Physiology and Pathophysiology of the Digestive Tract group, the gastroenterology line investigates the integrated function of the intestinal tract including secretion, motility and absorption in health and disease. It also studies the interactions of intestinal inflammation with some aspects of enteric flora in inflammatory bowel disease. The liver diseases group deals with viral hepatitis and liver cirrhosis and its complications. And the digestive transplants group studies mostly liver transplantation and the quality of life after it.

This area includes as well the health care research group. The aim of this group is to generate knowledge in the specific area of activity of nurses and collaborate with other health professionals to improve care given to patients.

Publications

115

total

678.821

impact factor

5.868

average impact factor

Director: Ramon Charco

team

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The Group’s current research is mainly focused on immunosuppression in adult and paediatric liver transplantation and treatment of hepatocarcinoma on cirrhosis. The new research lines are the microbiota on liver transplantation and molecular profiling in resectable colorectal liver metastases.
Our group has been a leader in the use and management of the new immunosuppressants in liver transplantation and also evaluating their effects in the short and long term follow-up. Today we participated in several clinical trials at the national and international scenarios. In one of them within the Pediatric area, we are the only Spanish Center that participates.
Since our group was a pioneer in the liver transplant in Spain we are investigating how these patients are after more than 20 years of transplantation.
Research on microbiota aims to understand the types of intestinal microbiota in cirrhotic patients from the day they are listed on the waiting list for liver transplantation until the 1st year post-transplant, and detecting the presence of bacterial DNA in blood and lymph splanchnic as confirmation of its alleged role in liver function through enteroportal circulation.
Molecular profiling in resectable colorectal liver metastases including KRAS, BRAF, PIK3CA, MET, HER2 and MSI aims to assess prognosis in the preoperative setting compare to clinical and histological factors.

11

total

47^.710

impact factor

4^.340

average impact factor

SELECTED ARTICLES

Castells L, Llaneras J, Campos-Varela I, Bilbao I, Crespo M, Len O, Rodríguez-Frías F, Charco R, Salcedo T, Esteban JI, Esteban-Mur R.
Sofosbuvir and daclatasvir in mono- and HIV-coinfected patients with recurrent hepatitis C after liver transplant.
Ann Hepatol. 2017 Jan-Feb 2017;16(1):86-93.
DOI: 10.5604/16652681.1226819.
IF: 1.678
Lagunes L, Len O, Sandiumenge A, Martínez-Saez E, Pumarola T, Bodro M, Macías A, Silva JT, Nuvials FX, Charco R, Moreso F, Pont T.
Successful multiple organ donation after donor brain death due to Actinomyces israelii meningitis.
Transpl Infect Dis. 2017 Aug;19(4).
DOI: 10.1111/tid.12711. Epub 2017 Jun 9.
IF: 1.65
Lai Q, Feys E, Karam V, Adam R, Klempnauer J, Oliverius M, Mazzaferro V, Pascher A, Remiszewski P, Isoniemi H, Pirenne J, Foss A, Ericzon BG, Markovic S, Lerut JP; European Liver Intestine Transplant Association (ELITA).
Hepatic Epithelioid Hemangioendothelioma and Adult Liver Transplantation: Proposal for a Prognostic Score Based on the Analysis of the ELTR-ELITA Registry.
Transplantation. 2017 Mar;101(3):555-564.
DOI 10.1097/TP.0000000000001603.
IF:3.678
Escolà-Vergé L, Los-Arcos I, José González-López J, Lung M, Bilbao I, Farré M, Pont T, Sandiumenge A, Gavaldà J, Len O.
Successful liver transplantation despite donor-transmitted ESBL-producing Klebsiella pneumoniae infection: Case report and review of the literature.
Transpl Infect Dis. 2017 Oct;19(5).
DOI: 10.1111/tid.12743. Epub 2017 Aug 2. Review.
IF:1.65
Agüero F, Forner A, Valdivieso A, Blanes M, Barcena R, Manzardo C, Rafecas A, Castells L, Abradelo M, Barrera-Baena P, González-Diéguez L, Salcedo M, Serrano T, Jiménez-Pérez M, Herrero JI, Gastaca M, Aguilera V, Fabregat J, Del Campo S, Bilbao I, Romero CJ, Moreno A, Rimola A, Miro JM; FIPSE Investigators.
Human immunodeficiency virus-infected liver transplant recipients with incidental hepatocellular carcinoma: A prospective multicenter nationwide cohort study.
Liver Transpl. 2017 May;23(5):645-651.
DOI: 10.1002/lt.24741.
IF: 3.91

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