Vascular Biology and Metabolism (VAM)

Overview

The Vascular Biology and Metabolism (VAM) area was created to enable a comprehensive, cooperative and multidisciplinary approach to research, development and transference of solutions for a group of diseases that are the leading cause of morbidity and mortality in the world: cardio- and neurovascular diseases, diabetes-metabolic syndrome and kidney failure.

This area also includes a group focused on Ophtalmology research and the Medical Molecular Imaging multidisciplinary group.

Publications

230

total

1,274.219

impact factor

5.542

average impact factor

Director: Daniel Serón Micas

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In 2017 the TRITON study, aimed to evaluate the utility of intravenous immunoglobulins and rituximab in the treatment of chronic humoral rejection was concluded, showing that this treatment is not efficient in the modification of the natural history of chronic humoral rejection. Also, a fruitful collaboration with the Oslo group allowed the publication of the results of a large protocol biopsy study showing that early subclinical inflammation favors the progression of interstitial fibrosis and the appearance of de novo donor specific antibodies and a second study showing that the presence of early inflammation depends on both, tacrolimus levels and mycophenolate mofetil dose suggesting that early inflammation can be prevented by avoiding under-immunosuppression. Finally, the results of a multicenter study evaluating the utility of microarrays to improve the accuracy of the histological diagnosis in renal allograft biopsies, has been published.

16

total

55^.884

impact factor

3^.493

average impact factor

SELECTED ARTICLES

Tacrolimus and mycophenolate regimen and subclinical tubulo-interstitial inflammation in low immunological risk renal transplants.
Torres IB, Reisaeter AV, Moreso F, Asberg A, Vidal M, Garcia-Carro C, Midtvedt K, Reinholt FP, Scott H, Castella E, Salcedo M, Dorje C, Sellares J, Azancot MA, Perello M, Holdaas H, Seron D
Transpl Int. 2017 Nov;30(11):1119-1131.
doi: 10.1111/tri.13002. Epub 2017 Jul 27.
IF: : 3,079
Real time central assessment of kidney transplant indication biopsies by microarrays: The INTERCOMEX Study.
Halloran PF, Reeve J, Akalin E, Aubert O, Bohmig GA, Brennan D, Bromberg J, Einecke G, Eskandary F, Gosset C, Duong Van Huyen JP, Gupta G, Lefaucheur C, Malone A, Mannon RB, Seron D, Sellares J, Weir M, Loupy A
Am J Transplant. 2017 Apr 27.
doi: 10.1111/ajt.14329.
IF: 6,165
The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology.
Am J Transplant. 2017 Jan;17(1):28-41. doi: 10.1111/ajt.14107.
Loupy A, Haas M, Solez K, Racusen L, Glotz D, Seron D, Nankivell BJ, Colvin RB, Afrouzian M, Akalin E, Alachkar N, Bagnasco S, Becker JU, Cornell L, Drachenberg C, Dragun D, de Kort H, Gibson IW, Kraus ES, Lefaucheur C, Legendre C, Liapis H, Muthukumar T, Nickeleit V, Orandi B, Park W, Rabant M, Randhawa P, Reed EF, Roufosse C, Seshan SV, Sis B, Singh HK, Schinstock C, Tambur A, Zeevi A, Mengel M
Am J Transplant. 2017 Jan;17(1):28-41. Year: 2017
DOI: 10.1111/ajt.14107
IF: 6,165
Fascin-1 is released from proximal tubular cells in response to calcineurin inhibitors (CNIs) and correlates with isometric vacuolization in kidney transplanted patients.
Jacobs-Cacha C, Torres IB, Lopez-Hellin J, Cantarell C, Azancot MA, Roman A, Moreso F, Seron D, Meseguer A, Sarro E
Am J Transl Res. 2017 Sep 15;9(9):4173-4183. eCollection 2017.
IF: 2,829
Inflammation in Early Kidney Allograft Surveillance Biopsies With and Without Associated Tubulointerstitial Chronic Damage as a Predictor of Fibrosis Progression and Development of De Novo Donor Specific Antibodies.
García-Carro C, Dörje C, Åsberg A, Midtvedt K, Scott H, Reinholt FP, Holdaas H, Seron D, Reisæter AV.
Transplantation. 2017 Jun;101(6):1410-1415.
doi: 10.1097/TP.0000000000001216.
IF: 3.678

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Vascular Biology and Metabolism (VAM)

Overview

Publications

Director: Daniel Serón Micas

Research Areas