Neurosciences

Overview

The Neuroscience area is consolidating its position as one of the largest clusters of research labs working on neurological diseases across Europe. Thirteen groups are currently part of this area, working closely with top clinicians at the hospital. The area encompasses different aspects related to neuroscience, such as neural development, neurodegeneration, neuroimmunology, neurological pain, mental health, neurosurgery or pediatric neurology.

There are groups also focused on cell signaling and apoptosis and translational bioinformatics.

Publications

183

total

815.974

impact factor

4.459

average impact factor

Director: Miquel Vila Bove

team

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In 2017, as our most important study, we have developed a new therapeutic strategy to selectively decrease the brain levels of ?-synuclein, a protein believed to be involved in the iniation and progression of Parkinson’s disease (PD), within the type of neurons most susceptible to degeneration in this common neurodegenerative disease. This technique is based on the intranasal administration of chemically-modified oligonucleotides. In addition, we have shown that the selective genetic ablation in dopaminergic neurons of the lysosomal enzyme glucocerebrosidase (GBA), mutations of which are associated with an increased risk of PD, does not result in neurodegeneration, thus indicating that a loss of GBA function is not sufficient by itself to cause PD.

7

total

27^.296

impact factor

3^.899

average impact factor

SELECTED ARTICLES

Selective ?-Synuclein Knockdown in Monoamine Neurons by Intranasal Oligonucleotide Delivery: Potential Therapy for Parkinson’s Disease
Alarcón-Arís D., Recasens A., Galofré M., Carballo-Carbajal I., Zacchi N., Ruiz-Bronchal E., Pavia-Collado R., Chica R., Ferrés-Coy A., Santos M., Revilla R., Montefeltro A., Fariñas I., Artigas F., Vila M.* and Bortolozzi A.* (*co-corresponding Authors)
Molecular Therapy 26(2):550-567 (2018) Epub 2017 Nov 29.
doi: 10.1016/j.ymthe.2017.11.015
Involvement of Cellular Prion Protein in ?-Synuclein Transport in Neurons
Urrea L., Segura-Feliu M., Masuda-Suzukake M., Hervera A., Pedraz L., Aznar J.M., Vila M., Samitier J., Torrents E., Ferrer .I, Gavín R., Hagesawa M. and Del Río J.A.
Molecular Neurobiology 55(3):1847-1860 (2018) Epub 2017 Feb 22
doi: 10.1007/s12035-017-0451-4.
Monitoring Autophagy in Muscle Stem Cells
García-Prat L., Muñoz-Cánoves P. and Martínez-Vicente M.
Methods in Molecular Biology 1556:255-280 (2017)
doi: 10.1007/978-1-4939-6771-1_14.
Cerebellar neurodegeneration in a new rat model of episodic hepatic encephalopathy
García-Lezana T., Oria M., Romero-Giménez J., Bové J., Vila M., Genescà J., Chavarria L. and Cordoba J.
Journal of Cerebral Blood Flow and Metabolism 37(3):927-937 (2017)
doi: 10.1177/0271678X16649196.
Glucocerebrosidase deficiency in dopaminergic neurons induces microglial activation without neurodegeneration
Soria F.N., Engeln M., Martinez-Vicente M., Glangetas C., Lopez-Gonzalez M.J., Dovero S., Dehay B., Normand E., Vila M., Favereaux A., Georges F., Lo Bianco C., Bezard E. and Fernagut P.O.
Human Molecular Genetics 26(14):2603-2615 (2017)
doi: 10.1093/hmg/ddx120

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Neurosciences

Overview

Publications

Director: Miquel Vila Bove

Research Areas