Digestive and Liver Diseases

Overview

The Digestive & Liver Diseases research area is composed by four groups, whose main goal is the study of the Digestive System diseases. In the Physiology and Pathophysiology of the Digestive Tract group, the gastroenterology line investigates the integrated function of the intestinal tract including secretion, motility and absorption in health and disease. It also studies the interactions of intestinal inflammation with some aspects of enteric flora in inflammatory bowel disease. The liver diseases group deals with viral hepatitis and liver cirrhosis and its complications. And the digestive transplants group studies mostly liver transplantation and the quality of life after it.

This area includes as well the health care research group. The aim of this group is to generate knowledge in the specific area of activity of nurses and collaborate with other health professionals to improve care given to patients.

Publications

115

total

678.821

impact factor

5.868

average impact factor

Director: Fernando Azpiroz Vidaur

team

group-zoom

zoom

group-download

download

In 2017 the group has maintained a high level of productivity (see publications) and capacity to attract resources (see research projects). A new research line on microinflammation of the digestive tract (eosinophilic esophagitis and ulcerative colitis) has been incorporated with competitive funding. This line complements the studies on substructural alterations identified in patients with irritable bowel syndrome. The group has fostered collaborative studies and networking in areas related to alterations of intestinal function, sub-structural alterations, inflammation, microbiota and digestive symptoms. Dr. Alonso has been recognized with the Rising Star award and the activity of the group has attracted considerable mediatic interest in television, radio and press, especially in relation to the work in the area of biogastronomy in collaboration with prestigious chefs ( Celler de Can Roca)

37

total

277^.332

impact factor

7^.495

average impact factor

SELECTED ARTICLES

Mego M, Manichanh C, Accarino A, Campos D, Pozuelo M, Varela E, Vulevic J, Tzortzis G, Gibson G, Guarner F, Azpiroz F.
Metabolic adaptation of colonic microbiota to galactooligosaccharides: a proof-of-concept-study.
Aliment Pharmacol Ther 45(6):670-680, 2017.DOI 10.111/apt.13931
IF: 7,286
Martínez C, Rodiño-Janeiro B, Lobo B, Stanifer ML, Klaus B, Granzow M, González-Castro AM, Salvo-Romero E, Alonso-Cotoner C, Pigrau M, Roeth R, Rappold G, Huber W, González-Silos R, Lorenzo J, de Torres I, Azpiroz F, Boulant S, Vicario M, Niesler B, Santos J.
miR-16 and miR-125b are involved in barrierfunction dysregulation through the modulation ofclaudin-2 and cingulin expression in the jejunumin IBS with diarrhea.
Gut. 2017 Sep; 66(9):1537-1538. doi: 10.1136/gutjnl-2016-311477.
IF: 16,658
Barba E, Accarino A, Azpiroz F.
Correction of abdominal distension by biofeedback-guided control of abdomino-thoracic muscular activity in a randomized, placebo-controlled trial.
Clin Gastroenterol Hepatol 15(12):1922-1929,doi10.1016/jcgh
IF: 7,398
Costea PI, Zeller G, Sunagawa S, Pelletier E, Alberti A, Levenez F, Tramontano M, Driessen M, Hercog R, Jung FE, Kultima JR, Hayward MR, Coelho LP, Allen-Vercoe E, Bertrand L, Blaut M, Brown JRM, Carton T, Cools-Portier S, Daigneault M, Derrien M, Druesne A, de Vos WM, Finlay BB, Flint HJ, Guarner F, Hattori M, Heilig H, Luna RA, van Hylckama Vlieg J, Junick J, Klymiuk I, Langella P, Le Chatelier E, Mai V, Manichanh C, Martin JC, Mery C, Morita H, O’Toole PW, Orvain C, Patil KR, Penders J, Persson S, Pons N, Popova M, Salonen A, Saulnier D, Scott KP, Singh B, Slezak K, Veiga P, Versalovic J, Zhao L, Zoetendal EG, Ehrlich SD, Dore J, Bork.
Towards standards for human fecal sample processing in metagenomic studies.
Nat Biotechnol. 2017 Nov;35(11):1069-1076. doi: 10.1038/nbt.3960
IF: 41,667
Pascal V, Pozuelo M, Borruel N, Casellas F, Campos D, Santiago A, Martinez X, Varela E, Sarrabayrouse G, Machiels K, Vermeire S, Sokol H, Guarner F,
Manichanh C. A microbial signature for Crohn’s disease.
Gut. 2017 Feb 7. pii: gutjnl-2016-313235. doi: 10.1136/gutjnl-2016-313235.
IF: 16,658

View all publications