Neurosciences

Overview

The Neuroscience area is consolidating its position as one of the largest clusters of research labs working on neurological diseases across Europe. Thirteen groups are currently part of this area, working closely with top clinicians at the hospital. The area encompasses different aspects related to neuroscience, such as neural development, neurodegeneration, neuroimmunology, neurological pain, mental health, neurosurgery or pediatric neurology.

There are groups also focused on cell signaling and apoptosis and translational bioinformatics.

Publications

183

total

815.974

impact factor

4.459

average impact factor

Director: Fco. Xavier de la Cruz Montserrat

team

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During 2017, the activities of the Translational Bioinformatics group have focused on its main line of research, aimed at achieving a better understanding of the molecular basis of the disease. On the one hand, the methodological research of our group has led to the development of new bioinformatics tools for the identification of pathogenic variants in sequencing projects. On the other hand, we have devoted important efforts to the biomedical/clinical application of our work, in collaboration with different groups from the Vall d’Hebron Institute of Research (VHIR) and external institutions.

6

total

30^.793

impact factor

5^.132

average impact factor

SELECTED ARTICLES

PMut: a web-based tool for the annotation of pathological variants on proteins, 2017 update.
Lopez-Ferrando V, Gazzo A, de la Cruz X, Orozco M, Gelpi JL.
Nucleic Acids Res. 2017 Apr. 17; 45(W1):W222-W228.
DOI: 10.1093/nar/gkx313
IF: 10,162
Elucidating the molecular basis of msh2-deficient tumors by combined germline and somatic analysis.
Vargas-Parra GM, Gonzalez-Acosta M, Thompson BA, Gomez C, Fernandez A, Damaso E, Pons T, Morak M, Del Valle J, Iglesias S, Velasco A, Solanes A, Sanjuan X, Padilla N, de la Cruz X, Valencia A, Holinki-Feder E, Brunet J, Feliubadalo L, Lazaro C, Navarro M, Pineda M, Capella G
Int J Cancer. 2017 Oct 1;141(7):1365-1380. doi: 10.1002/ijc.30820
IF: 6,513
Identification and characterization of the novel point mutation m.3634A>G in the mitochondrial MT-ND1 gene associated with LHON syndrome
Carreno-Gago L, Gamez J, Camara Y, Alvarez de la Campa , Aller-Alvarez JS, Moncho D, Salvado M, Galan A, de la Cruz X, Pinos T, Garcia-Arumi E Carreno-Gago L, Gamez J, Camara Y, Alvarez de la Campa , Moncho D, Salvado M, Galan A, de la Cruz X, Pinos T, Garcia-Arumi E.
Biochim Biophys Acta. 2017 Jan;1863(1):182-187.
doi: 10.1016/j.bbadis.2016.09.002.
IF: 5,476
Development of pathogenicity predictors specific for variants that do not comply with clinical guidelines for the use of computational evidence.
de la Campa EA, Padilla N, de la Cruz X
BMC Genomics. 2017 Aug 11;18(Suppl 5):569.
DOI: 10.1186/s12864-017-3914-0.
IF: 3,729
Early Versus Late Diagnosis of Complement Factor I Deficiency: Clinical Consequences Illustrated in Two Families with Novel Homozygous CFI Mutations.
Franco-Jarava C, Alvarez de la Campa , Solanich X, Morandeira-Rego F, Mas-Bosch V, Garcia-Prat M, de la Cruz X, Martin-Nalda A, Soler-Palacin P, Hernandez-Gonzalez M, Colobran R
J Clin Immunol. 2017 Nov;37(8):781-789.
DOI: 10.1007/s10875-017-0447-x.
IF: 3,253

Neurosciences

Overview

Publications

Director: Fco. Xavier de la Cruz Montserrat

Research Areas