Oncology

Overview

The Oncology research area is composed by nine groups addressing the principal unsolved issues in cancer. Their research covers fields such as child and adolescent cancer, melanoma, Gynecology, Urology, cancer stem cells and the molecular mechanisms of the tumor pathologies.

There are also three groups from the CIBBIM-Nanomedicine. These groups study the use of nanotechnology in biomedical applications to improve therapeutic strategies and diagnostics.

Publications

120

total

757.123

impact factor

6.309

average impact factor

Director: Josep Sánchez de Toledo

team

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In 2017, the group of Translational Research in Child and Adolescent Cancer has kept expanding their research lines, namely research on Soft Tissue Sarcomas (e.g. Rhabdomyosarcoma), Neural tumours (e.g. Neuroblastoma, Ependymoma) and the program of personalized medicine. This research yielded the publication of 21 new international papers with an accumulated impact factor (JCI 2016) of 124,831. Moreover, within this period the group has been awarded with 2 new grants from Instituto de Salud Carlos III (PI17/00564) and Asociación Española Contra el Cáncer-Junta de Barcelona that will start on 2018. In addition, the group has continued with the consolidated collaborations with biotech companies with the aim of testing and developing new therapeutic tools against the most aggressive pediatric solid tumors.

22

total

124^.851

impact factor

5^.675

average impact factor

SELECTED ARTICLES

Cunha R, Zago MA, Querol S, Volt F, Ruggeri A, Sanz G, Pouthier F, Kogler G, Vicario JL, Bergamaschi P, Saccardi R, Lamas CH, Diaz-de-Heredia C, Michel G, Bittencourt H, Tavella M, Panepucci RA, Fernandes F, Pavan J, Gluckman E, Rocha V.
Impact of CTLA4 genotype and other immune response gene polymorphisms on outcomes after single umbilical cord blood transplantation. Blood. 2017 Jan 26;129(4):525-532. doi: 10.1182/blood-2016-06-722249.
IF: 13,164

Almazan-Moga A, Zarzosa P, Vidal I, Molist C, Giralt I, Navarro N, Soriano A, Segura MF, Alfranca A, Garcia-Castro J, Sanchez de Toledo J, Roma J, Gallego S.
Hedgehog Pathway Inhibition Hampers Sphere and Holoclone Formation in Rhabdomyosarcoma.
Stem Cells Int. 2017;2017:7507380.
doi: 10.1155/2017/7507380.
IF: 3,54

Segura MF, Jubierre L, Li S, Soriano A, Koetz L, Gaziel-Sovran A, Masanas M, Kleffman K, Dankert JF, Walsh MJ, Hernando E.
Kruppel-like factor 4 (KLF4) regulates the miR-183~96~182 cluster under physiologic and pathologic conditions.
Oncotarget. 2017 Feb 17.
doi: 10.18632/oncotarget.15459.
IF: 5,168

Almazan-Moga A, Zarzosa P, Molist C, Velasco P, Pyczek J, Simon-Keller K, Giralt I, Vidal I, Navarro N, Segura MF, Soriano A, Navarro S, Tirado OM, Ferreres JC, Santamaria A, Rota R, Hahn H, Sanchez de Toledo J, Roma J, Gallego S.
Ligand-dependent Hedgehog pathway activation in Rhabdomyosarcoma: the oncogenic role of the ligands. Br J Cancer. 2017 Oct 24;117(9):1314-1325.
doi: 10.1038/bjc.2017.305.
IF: 6,176

Barzaghi F, Amaya Hernandez LC, Neven B, Ricci S, Kucuk ZY, Bleesing J, Nademi Z, Slatter MA, Ulloa ER, Shcherbina A, Roppelt A, Worth A, Silva J, Aiuti A, Murguia-Favela L, Speckmann C, Carneiro-Sampaio M, Fernandes JF, Baris S, Ozen A, Karakoc-Aydiner E, Kiykim A, Schulz A, Steinmann S, Notarangelo LD, Gambineri E, Lionetti P, Shearer WT, Forbes L, Martinez C, Moshous D, Blanche S, Fisher A, Ruemmele FM, Tissandier C, Ouachee-Chardin M, Rieux-Laucat F, Cavazzana M, Qasim W, Lucarelli B, Albert MH, Kobayashi I, Alonso L, Diaz De Heredia C, Kanegane H, Lawitschka A, Seo JJ, Gonzalez-Vicent M, Diaz MA, Goyal RK, Sauer MG, Yesilipek A, Kim M, Yilmaz-Demirdag Y, Bhatia M, Khlevner J, Richmond Padilla EJ, Martino S, Montin D, Neth O, Molinos-Quintana A, Valverde-Fernandez J, Broides A, Pinsk V, Ballauf A, Haerynck F, Bordon V, Dhooge C, Garcia-Lloret ML, Bredius RG, Kalwak K, Haddad E, Seidel MG, Duckers G, Pai SY, Dvorak CC, Ehl S, Locatelli F, Goldman F, Gennery AR, Cowan MJ, Roncarolo MG, Bacchetta R.
Long-term follow up of IPEX syndrome patients after different therapeutic strategies: an international multicenter retrospective study.
J Allergy Clin Immunol. 2017 Dec 11.
pii: S0091-6749(17)31893-6.
doi: 10.1016/j.jaci.2017.10.041.
IF: 13,08

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Oncology

Overview

Publications

Director: Josep Sánchez de Toledo

Research Areas